Evaluation of Alpha1 Antitrypsin Deficiency-Associated Mutations in People with Cystic Fibrosis.

J Clin Med · 2025 · PMC12524791 · PMID 41095865

Europe PMC DOI

hedged sentences

0.0570

closest p · 1.1× alpha

0.0570

boldest claim

The sentences

close to significancep = 0.057so close (0.05 < p ≤ 0.1)

CF cases carrying any SERPINA1 mutation showed a numerical increase in the number of mild exacerbations close to significance (10.7 (9.7) vs. 13.1 (12.1); p = 0.057), with no difference in severe exacerbations (2.1 (4.1) vs. 2.3 (3.1); p = 0.415) over the follow-up.

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showed a trendno p-value reported

A crude bivariate comparison of FEV 1 on the index date between cases carrying any SERPINA1 mutation versus the rest of the cohort showed a trend towards a worsening for those carrying any AATD mutation ( Table 1 ).

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