Toxicological Assessment of <i>Origanum majorana</i> L.: Evaluation of Its Cytotoxicity, Genotoxicity, and Acute Oral Toxicity.

Comet Assay Results The comet assay demonstrated a statistically highly significant increase in DNA damage (%DNA T ) at O. majorana extract concentrations of 100 and 200 μg/mL compared to the control group ( p < 0.001), whereas the 10 μg/mL concentration did not differ significantly from the control ( p > 0.05).

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CK levels varied but did not reach statistical significance, and additional metabolic markers (CO 2 , NH 3 , lipase) showed only minimal changes, together suggesting an absence of overt cardiac or metabolic toxicity.

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