Effects of Rare Coding Variants in Severe Early-Onset Obesity Genes in the Population-Based UK Biobank Study.

J Clin Endocrinol Metab · 2025 · PMC12527455 · PMID 40036808

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nominally significantno p-value reported

A nominally significant positive interaction effect was observed between BMI PGS and carriage of damaging missense (DMG-MISS) variants in MC4R with respect to childhood body size at age 10 (β = .07, SE = 0.04, P = .049; Table S5 ( 59 )).

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