Behavioral benefits of GSK-3β inhibition and state-dependent microtubule signatures in the <i>Fmr1</i>-KO mouse.

GSK-3β inhibition rescued this impairment, with SB216763 apparently demonstrating better efficacy than AF3581, since the latter failed to reach statistical significance.

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In the pharmacological experiment, expression of hippocampal Acet/Total-Tub was still increased in Fmr1 -KO mice with a trend very close to significance when compared to WT counterparts, while Tyr/Glu-Tub was not found decreased as it was observed in the first cohort of untreated animals.

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