Human <i>in vivo</i> assessment of ketamine binding of the serotonin transporter-follow up at a higher dose.

A previous [ 11 C]DASB PET study in healthy subjects by our team revealed no significant ketamine SERT occupancy at the routine antidepressant dose of 0.5 mg/kg body weight but showed a trend toward an association between SERT occupancy and ketamine plasma levels ( Spies et al., 2018 ).

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We previously reported that a 0.5 mg/kg body weight dose of ketamine did not significantly bind to SERT in healthy human subjects assessed with PET but observed a positive trend between binding and ketamine plasma levels.

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