Elastic net regressions of DNA-methylation and pubertal age We restricted elastic net regression analyses to probes that (1) passed quality control filters described in the Supplementary Methods and are present on both the 450k and EPIC arrays, (2) had an intraclass correlation coefficient (ICC) > 0.4 in 19 TTP technical replicates, (3) were nominally significant probes from the EWAS of pubertal age in each sex in TTP.
1
—
—