When examining individual clinical outcomes, circulating IL-18R1 levels significantly predicted weight response (AUC = 0.644, p = 0.03), while associations with changes in HbA1c and UACR did not reach statistical significance ( Figure 3 B).
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Identification of IL18/IL18R1 signaling as a predictive biomarker of SGLT2 inhibitor efficacy in type 2 diabetes.
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