Absolute bacterial abundance was lower in HSD-fed mice after 2 weeks, although this difference did not reach statistical significance (1.1 × 10 9 ± 3.4 × 10 8 vs. 5.8 × 10 8 ± 1.7 × 10 8 , p = 0.144, paired t-test).
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<b>A sucrose-rich diet promotes</b> <i><b>Clostridioides difficile</b></i> <b>carriage without prior antibiotics and significantly exacerbates both acute disease and long-term colonization</b>.
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