Probing the molecular determinants of Ty1 retrotransposon restriction specificity in yeast.

PLoS Genet · 2025 · PMC12530519 · PMID 41066520

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marginally significantno p-value reported

Dimer-2 mutations decrease restriction activity by less than an order of magnitude, that is not significant in p18m(F323S) and is marginally significant in Drt2m(SSS).

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highly significantno p-value reported

However, Dimer-2 does contribute to Gag function as Ty1c Gag(F323S) lowers retromobility approximately two orders of magnitude and is highly significant ( S2C Fig ).

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a clear trendno p-value reported

Line 250, These exchange factors show a clear trend at the higher levels.

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