Association between fentanyl use and reduced risk of tension pneumothorax in extremely preterm infants born at 22-23 weeks' gestation: a retrospective case-control study.

Front Pediatr · 2025 · PMC12531072 · PMID 41113566

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

0.2500

boldest claim

The sentences

borderline significantp = 0.05actually significant

Analyses limited to births at tertiary care centers (excluding primary and secondary institutions) showed a borderline significant association between fentanyl use and lower tension pneumothorax risk (Adjusted OR: 0.11, 95% CI: 0.01–0.99, p = 0.05).

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did not reach statistical significancep = 0.25not close (p > 0.1)

Exploratory analyses revealed a trend toward a protective effect with fentanyl infusion rates, although this association did not reach statistical significance (Coefficient = −1.60, p = 0.25).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.