Single-nucleotide polymorphisms of donor <i>CYP3A5</i> and recipient <i>ABCB1</i> affect tacrolimus intrapatient variability in living donor liver transplantation: a retrospective cohort study.

Ann Surg Treat Res · 2025 · PMC12531637 · PMID 41112358

Europe PMC DOI

hedged sentences

0.0510

closest p · 1.0× alpha

0.0900

boldest claim

The sentences

near-significantP = 0.051so close (0.05 < p ≤ 0.1)

Excluding donor variables from the multivariate analysis (not reported in this study) showed a near-significant link between high IPV and recipients’ CYP3A5 6986A>G GA and GG genotypes (OR, 3.975; 95% CI, 0.992–15.930, P = 0.051), along with ABCB1 1236C>T CC and CT, and glucose levels of 120 mg/dL at the 3-month follow-up.

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marginally significantP = 0.090so close (0.05 < p ≤ 0.1)

The recipient CYP3A5 6986A>G genotypes GA and GG and γ-GT ≥70 U/L at 3 months were marginally significant (P = 0.090 and P = 0.102, respectively).

also in 26,082 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.

Single-nucleotide polymorphisms of donor &lt;i&gt;CYP3A5&lt;/i&gt; and recipient &lt;i&gt;ABCB1&lt;/i&gt; affect tacrolimus intrapatient variability in living donor liver transplantation: a retrospective cohort study.

The sentences

Single-nucleotide polymorphisms of donor <i>CYP3A5</i> and recipient <i>ABCB1</i> affect tacrolimus intrapatient variability in living donor liver transplantation: a retrospective cohort study.