Diabetic bone fragility through advanced glycation end product-collagen axis: Mechanisms and therapy of sodium glucose cotransporter 2 inhibitors.

World J Diabetes · 2025 · PMC12531808 · PMID 41113476

Europe PMC DOI

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0.0001

closest p · 0.0× alpha

0.0010

boldest claim

The sentences

a decreasing trendP < 0.0001actually significant

Moreover, the bone resorption marker β-CrossLaps of COL1 C-terminal telopeptide (β-CTX) also showed a decreasing trend (standardized mean difference = -0.46, 95%CI: -0.68 to -0.24, P < 0.0001).

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highly significantP < 0.001actually significant

A meta-analysis further revealed that the overall RR for any type of fracture in T1DM patients was 1.88 [95% confidence interval (CI): 1.52-2.32], indicating a highly significant increase in fragility fracture risk even among young adults with T1DM ( P < 0.001)[ 27 ].

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did not reach statistical significanceno p-value reported

A cross-sectional study in older adults with T2DM revealed that patients with diabetic kidney disease (DKD) had lower β-CTX and P1NP levels than their non-DKD counterparts did, although the differences did not reach statistical significance, suggesting a modest influence of renal function decline on BTMs[ 44 ].

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