Meta-analysis and Meta-regression for Uncertain Areas and the Estimation of Possible Benefit of Future Therapies.

Finally, meta-regression can also be used for the estimation of the effect of molecules under investigation or those without much clinical evidence; for example, after the results of the first long-term studies with inclisiran – the first RNA silencer therapy that inhibits the synthesis of PCSK9 – which reported the efficacy of monoclonal antibodies inhibiting the protein for lowering LDL cholesterol; moreover, a clear trend in the reduction of major cardiovascular events (MACE) was also observed.

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