Early-life serological profiles and the development of natural protective humoral immunity to Streptococcus pyogenes in a high-burden setting.

Nat Med · 2025 · PMC12532705 · PMID 40781379

Europe PMC DOI

hedged sentence

0.1400

closest p · 2.8× alpha

0.1400

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showed a trendP = 0.14not close (p > 0.1)

Compared to individuals with high IgG to a single antigen, those with titers above the 50% protective threshold for two or more antigens showed a trend toward reduced risk of events (OR 0.32, CI 0.07–1.46, P = 0.14).

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