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Relationship Between Neutrophil Count and 90-Day Outcomes and Effect of Dual Antiplatelet Therapy in Patients With Acute Ischemic Stroke or Transient Ischemic Attack: A Post Hoc Analysis of the INSPIRES Trial.

J Am Heart Assoc · 2025 · PMC12533628 · PMID 40654232

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The CHANCE‐3 (Colchicine in High‐Risk Patients With Acute Minor‐to‐Moderate Ischemic Stroke or Transient Ischemic Attack) study tried to address the residual risk of stroke with the low dose of colchicine based on C‐reactive protein as an inclusion, but the results did not reach statistical significance. 7 Therefore, the specific mechanisms by which inflammation affects early stroke recurrence remain unclear.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.