State-dependent reactivity of anterior cingulate cortex neurochemistry and downstream autonomic arousal in intrusive thinking.

The model analyzing Glx revealed a marginally significant Condition by Group interaction ( F 1,47 = 3.19; p = .080, η p 2 = 0.06), indicating a trend toward a decrease in the pathological group from pre (3.82 ± 0.34 i.u.) to post-induction (3.73 ± 0.37 i.u.).

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Following the experimental induction of intrusive thinking, the non-pathological group showed a trend toward reduced GABA + and increased Glx concentrations, consistent with prior findings on stress-induced changes in mPFC GABA + and Glx levels in healthy humans (Cooper et al. 2021 ; Hasler et al. 2010 ; Houtepen et al. 2017 ; Zwanzger et al. 2013 ) and rodents (e.g., Bedse et al. 2015 ; de Groote and Linthorst 2007 ).

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