Evaluation of the podoplanin/C-type lectin-like receptor-2 (CLEC-2) pathway as a mediator of platelet and coagulation activation in sickle cell disease.

Res Pract Thromb Haemost · 2025 · PMC12538053 · PMID 41127644

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showed a trendno p-value reported

Finally, expression of both PDPN and CLEC-2 in LPAs was positively correlated with established laboratory markers of coagulation and platelet and endothelial activation, such as D-dimer, P-selectin, VWF, and reticulocyte counts, and showed a trend toward association with a history with VOC.

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