Sex-specific benefits of a combined supplementation of B vitamins, nicotinamide riboside, folate and cobalamin, in a murine model of heart failure.

Females also showed a trend towards a lower mortality rate and a higher median survival in TAC-3VitB group in comparison with TAC-ND group, although it remained below study’s defined significance level (Fig. 1 A and B).

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While the significant reduction in mortality in males is a strong argument in favor of the efficacy of this B vitamin cocktail in slowing the progression of the disease, the improvement in physical capacities observed in both sexes is also highly significant, since it demonstrates better adaptation of the treated animals when the body’s energy demand increases.

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