Upregulation of Na/H Exchanger in Astrogliosis and Early Alzheimer's Disease Pathogenesis.

Although the changes did not reach statistical significance, the trend was notable in the amygdala region of AD brains with a higher mean soma volume by 42.6% (p = 0.4199) ( Fig. 2B ), an increase in mean dendrite volume by 28.1% (p = 0.18) ( Fig. 2C ), and a higher mean process branch number by 32.3% (p = 0.19) ( Fig. 2D ), compared to CTRL.

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Figure 2 shows that compared to CTRL brains, 3 regions of the AD brains (cortex, hippocampus, and amygdala) displayed an overall trend of larger soma and dendrite volumes, and increased branch numbers.

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