Multi-omics analysis reveals Angelica dahurica radix extract alleviates migraine in rats via gut microbiota-metabolome-gut-brain axis regulation.

Front Pharmacol · 2025 · PMC12540402 · PMID 41132525

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an increasing trendno p-value reported

3.2 BZ ameliorated NTG-induced migraine symptoms in rats Throughout the experimental period ( Figure 2A ), the Model group exhibited a slight decrease in body weight, while the groups of BZ and SS treatment groups demonstrated an increasing trend similar to the Normal group.

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showed a trendno p-value reported

Following BZ treatment, the relative peak areas of numerous metabolites, including 4-Amino-3-hydroxybenzoic acid and ProstaglandinA1, showed a trend of reverting towards the levels observed in the Normal group.

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