Barely Significant
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Sex-related hormonal variances and clinical outcomes in TAVR patients.

Clin Res Cardiol · 2025 · PMC12540518 · PMID 39992388

2
hedged sentences
0.0760
closest p · 1.5× alpha
0.0760
boldest claim

The sentences

a trend toward significancep = 0.076so close (0.05 < p ≤ 0.1)
showed a trendp = 0.076so close (0.05 < p ≤ 0.1)
In the multivariate analysis, statistical significance remained for IGF-1 (p = 0.043), while the other hormones showed a trend toward significance but with borderline p-values: PTH (p = 0.076), DHEA-S (p = 0.050), and cortisol (p = 0.062).

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A more recent meta-analysis also found that low DHEA-S was associated with an increased risk of total mortality in both men and women, although the association in women did not reach statistical significance [ 25 ].

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