Tumor immune microenvironment analysis in different pathologic responses to neoadjuvant immunotherapy combined with chemotherapy in non-small cell lung cancer.

Transl Lung Cancer Res · 2025 · PMC12541850 · PMID 41132972

Europe PMC DOI

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0.0700

closest p · 1.4× alpha

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a decreasing trendP=0.07so close (0.05 < p ≤ 0.1)

Comparison of TIME in paired specimens of NSCLC before and after neoadjuvant IO-CT After receiving IO + CT treatment, the number of CD56bright NK cells and CD56dim NK cells in the stromal area significantly increased compared to before treatment (P=0.002, P=0.02, Figure 5A,5B ), while the number of Foxp3 + T cells in the stromal area showed a decreasing trend (P=0.07, Figure 5C ).

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showed a trendP=0.09so close (0.05 < p ≤ 0.1)

Additionally, the MPR/pCR group showed a trend toward longer DFS (P=0.09) ( Figure 2F ).

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an increasing trendP=0.09so close (0.05 < p ≤ 0.1)

The proportion of CD56dim NK cells in the tumor also showed an increasing trend (P=0.09, Figure 5H ).

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