Dual inhibition of IRAK1/TAK1 signaling in astrocytes reduces accelerated mortality in human APOE4 knock-in APPswe/PSEN1dE9/P301S-Tau triple transgenic mouse model.

J Neuroinflammation · 2025 · PMC12542347 · PMID 41121315

Europe PMC DOI

hedged sentences

0.1100

closest p · 2.2× alpha

0.1100

boldest claim

The sentences

did not reach statistical significancep = 0.11not close (p > 0.1)

7 F, G), although this difference did not reach statistical significance ( p = 0.11).

also in 111,027 other papers

a decreasing trendno p-value reported

RT-qPCR analysis further revealed a significant reduction in Cdkn1a (encoding p21) expression and a decreasing trend of Cdkn2a (encoding p16) in newborn neurons of E4-3Tg (A) mice (Fig. 7 H; n = 4 per group).

also in 47,180 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.