Suppression of adipocyte ABHD6 favors anti-inflammatory and adipogenic programs to preserve adipose tissue fitness in obesity.

Palmitate oxidation was elevated in the gWAT and exhibited an increasing trend in the iBAT ( p = 0.1), without any changes in the iWAT from AA-KO mice ( Figure 4 D).

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Also, the obesity-associated chemokines (CXCL1 and CXCL10 [ 45 ]) and the pro-inflammatory cytokine IL-2 [ 46 ] showed a decreasing trend in the AA-KO vs. controls ( Figure 2 O).

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As expected, basal glycerol release in gWAT adipocytes from ABHD6-deficient mice showed a trend toward reduction; however, stimulated glycerol release was increased, likely due to the marked decrease in HFD-induced inflammation in this depot, as metabolic inflammation is known to suppress adrenergic-stimulated pathways [ 1 , 66 ].

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