A population-based study of interactions between high-risk human papillomavirus infection and vaginal local cytokines CD4 CD8 IL-10 with cervical intraepithelial neoplasia.

Front Oncol · 2025 · PMC12549257 · PMID 41142594

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showed a trendno p-value reported

I: 0.21, 0.48, P-trend < 0.01).The 1st quartile levels of CD8 had the 66% and 76% decreased odds of CIN1 and CIN2/3 than the 4th quartile, respectively(for CIN1 OR = 0.34, 95% CI: 0.26, 0.45, P-trend < 0.01;for CIN2/3 OR = 0.24, 95% CI: 0.16, 0.38, P-trend < 0.01).CD4/CD8 levels and the risk of CIN showed a trend of first decreasing and then increasing.

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