ABCG5/ABCG8-independent mechanisms fail to maintain sterol balance in mice fed a high-cholesterol diet.

8.40 ± 2.11), but the difference between FNS on the PS-free diet compared with the cholesterol-supplemented diet failed to reach statistical significance.

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While there is an apparent trend toward increased expression of genes regulated by Srebp2 (Ldlr and Hmgcr) consistent with a reduction in cholesterol in the proximal small intestine, none of these differences reached statistical significance within sex.

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