The Crosstalk Between the Anterior Hypothalamus and the Locus Coeruleus During Wakefulness Is Associated with Low-Frequency Oscillations Power During Sleep.

Post hoc contrasts revealed that REM theta energy shows a negative statistical trend with the response of the anterior–superior hypothalamus (t = −1.81; p = 0.07) and a positive nominally significant association with the response of the posterior hypothalamus (t = 1.90; p = 0.05; Figure 2 A,B).

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Only subparts showing at least a statistical trend ( p < 0.1) with one of these sleep metrics were retained for the subsequent DCM analyses, ensuring that connectivity analyses focused on hypothalamic regions most likely to be functionally relevant to our sleep measures of interest.

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