Loss of melanocortin receptor accessory protein 2 in melanocortin-4 receptor neurons protect from obesity-associated autonomic and cardiovascular dysfunctions.

Cardiovasc Res · 2025 · PMC12551390 · PMID 40244925

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0.0800

closest p · 1.6× alpha

0.0800

boldest claim

The sentences

showed a trendP = 0.08so close (0.05 < p ≤ 0.1)

This index showed a trend ( P = 0.08) towards decrease in MC4R Cre /MRAP2 fl/fl mice relative to controls (see Supplementary material online , Figure S7B ), indicating that the ability of the baroreceptor reflex to buffer blood pressure fluctuations is impaired.

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