Neurofilament Light Chain as a Biomarker of Disease Progression in Lafora Disease.

Statistical significance is reported by the p value of the statistical test procedures and was assessed as significant (*, p < 0.05), strongly significant (**, p < 0.01), or highly significant (***, p < 0.001; ****, p < 0.0001).

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Of interest, some presymptomatic individuals (S0) already displayed elevated cNfL levels prior to clinical disease onset, although these differences did not reach statistical significance, while this trend was less evident for sNfL.

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