The cutaneous response to a mosquito bite is influenced by the diurnal rhythm.

In general, Chil3 showed a trend toward upregulation of gene expression across all time points and tissue examined, with statistical significance observed at ZT11 after both 1 h and 24 h of exposure on the ear skin, and after 24 h of exposure on the back skin at both ZT1 and ZT11 ( Figure 4 B).

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