Exploring Salivary Brain-Derived Neurotrophic Factor (BDNF) as a Potential Biomarker of Neuroplasticity in Older Adults Through Exergaming.

Cureus · 2025 · PMC12554297 · PMID 41146751

Europe PMC DOI

hedged sentence

0.0556

closest p · 1.1× alpha

0.0556

boldest claim

The sentences

approached significancep = 0.0556so close (0.05 < p ≤ 0.1)

While the one-tailed test approached significance (p = 0.0556), the two-tailed test did not (p = 0.111), suggesting a trend toward increased methylation following the intervention, though limited by sample size.

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