Metabolic-immune crosstalk in myocardial infarction: RLF and SMCHD1 identified as causal therapeutic targets via integrated lactylation-MR analysis.

Although SMCHD1 expression was elevated in the MI group relative to controls, this difference did not reach statistical significance ( Figure 5B ). 3.6 Validation of RLF and SMCHD1 dysregulation in the mouse MI model In the mouse MI model, serum RLF expression was significantly elevated at both mRNA and protein levels compared with sham controls (P < 0.0001; Figures 5C,F ).

also in 111,027 other papers