Diagnostic performance of adenosine deaminase activity in pleural fluid in tuberculous pleural effusion and relevant factors: a single-center experience with 1,491 consecutive patients.

Although the difference did not reach statistical significance, culture-positive TPE cases tended to have slightly higher mean ADA levels than culture-negative cases (60.5 IU/L vs. 57.5 IU/L, p = 0.1688).

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For the first time, we investigated a possible relationship between pleural ADA test accuracy and blood CD45 + relative count, however, we do not recommend routine measurement of blood CD45 + relative count in patients with pleurisy for two reasons: first, due to the additional cost burden, and second, the impact of CD45 + relative counts on accuracy may not be significant, as even the lowest value remained acceptable (0.91).

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