Impact of single nucleotide variants in estrogen genes on ovarian cancer risk: a systematic review and meta-analysis.

Endocr Oncol · 2025 · PMC12558086 · PMID 41158532

Europe PMC DOI

hedged sentences

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closest p · 1.0× alpha

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boldest claim

The sentences

borderline significantP = 0.05actually significant

For rs743572 ( CYP17A1 ), the dominant model yielded a borderline significant association (OR = 1.56; 95% CI: 1.00–2.45; P = 0.05), reinforcing the increased risk observed for the C allele in the main analysis.

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showed a trendP = 0.050actually significant

Overall, the results did not reveal statistically significant associations in any of the tested models, with the marginal exception of SNP rs743572 ( CYP17A1 ) under the dominant model, which showed a trend toward association (OR = 1.56; 95% CI: 1.00–2.45; P = 0.050), despite moderate heterogeneity ( I 2 = 55.6%).

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