Astrocytes showed a strong trend toward more skipping in the disease state, while excitatory neurons were, in contrast, prone to more inclusion, whereas dysregulation events among inhibitory neurons and oligodendrocytes were more evenly distributed between increased inclusion and skipping ( Figure 4A ).
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A single-cell, long-read, isoform-resolved case-control study of FTD reveals cell-type-specific and broad splicing dysregulation in human brain.
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