Barely Significant
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Pharmacological profiling in CLL patients during pirtobrutinib therapy and disease progression.

Blood Cancer J · 2025 · PMC12559276 · PMID 41145426

Europe PMCDOI
1
hedged sentence
0.0570
closest p · 1.1× alpha
0.0570
boldest claim

The sentences

did not reach statistical significancep = 0.057so close (0.05 < p ≤ 0.1)
Although all patients who progressed had baseline unmutated IGHV and XPO1 mutation ( n = 5), they did not reach statistical significance ( p = 0.057 for both) and need to be confirmed.

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