Comparison of Neurofactor Changes and Prognosis in Elderly Patients with Spontaneous Intracerebral Hemorrhage Treated with Endoscopic versus Conventional Craniotomy Surgery.

(3) Compared with preoperative levels, both groups showed a decreasing trend in SOD and NSE and an increasing trend in NGF and BDNF after surgery, with the observation group showing more significant and sustained changes over time (P < 0.05).

also in 38,133 other papers

The MISTIE III trial, a large multicenter randomized controlled study, demonstrated that image-guided minimally invasive surgery combined with thrombolysis could safely reduce hematoma volume and perihematomal edema, with potential improvement in functional outcomes among patients with large ICH, although the primary endpoint did not reach statistical significance. 17 Additionally, several updated meta-analyses have reaffirmed the benefits of minimally invasive approaches over conventional craniotomy, indicating lower mortality, better functional recovery, and fewer complications, particularly in elderly or high-risk populations. 18 , 19 These findings provide further evidence to support the clinical use of endoscopic evacuation in selected ICH patients and reinforce the present study’s conclusion that endoscopic surgery may be advantageous in elderly patients.

also in 75,868 other papers