Genetic Variations in Bitter Taste Receptors and COVID-19 in the Canadian Longitudinal Study on Aging.

Biomedicines · 2025 · PMC12562077 · PMID 41153757

Europe PMC DOI

hedged sentences

0.0580

closest p · 1.2× alpha

0.0580

boldest claim

The sentences

a trend toward significancep = 0.058so close (0.05 < p ≤ 0.1)

Although rs2234235 in TAS2R1 was associated with the spike antibody in the entire cohort (OR: 0.74; CI: 0.57, 0.98; p = 0.033), a subgroup analysis revealed a significant association only in patients with respiratory disease (OR: 0.48; CI: 0.27, 0.85; p = 0.012) and with a trend toward significance in patients with IMID (OR: 0.37; CI: 0.13, 1.04; p = 0.058).

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borderline significantp = 0.058so close (0.05 < p ≤ 0.1)

Additionally, rs3851584 in TAS2R14 showed a borderline significant association with the infection ( p = 0.058).

also in 2,689 other papers

showed a trendno p-value reported

Results : In the COVID-19 Questionnaire Study (N = 14,073), the rs117458236 (C) variant in TAS2R20 showed a trend toward an association with COVID-19 infection (OR = 1.95; 95% Confidence Interval (CI): 0.98, 3.51).

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