sTREM-1, HMGB1, CRP, PCT, sCD14-ST, IL-6, IL-10, sHLA-G, and Vitamin D in Relation to Clinical Scores and Survival in SIRS/Sepsis.

Biomedicines · 2025 · PMC12562215 · PMID 41153764

Europe PMC DOI

hedged sentences

0.0548

closest p · 1.1× alpha

0.1470

boldest claim

The sentences

borderline significancep = 0.0548so close (0.05 < p ≤ 0.1)

Nevertheless, correlation analyses revealed significant negative associations between sHLA-G plasma levels and pro-inflammatory HMGB1 ( p = 0.0475), eosinophil counts ( p = 0.0462), and SOFA scores ( p = 0.0548, borderline significance).

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did not reach statistical significancep = 0.147not close (p > 0.1)

In contrast, other biomarkers such as C-reactive protein (CRP) and triggering receptor expressed on myeloid cells-1 (TREM-1) did not reach statistical significance after adjustment for clinical covariates ( p = 0.147 and p = 0.176, respectively), ( Table 4 ).

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