Serum miR-34a as Indicator of Impaired Fibrinolytic Capacity in Pediatric Thrombosis Through Inadequate Regulation of the ACE/PAI-1 Axis.

As to the expression of miR-145-5p, a similar trend towards higher levels in the control population was observed, but did not reach statistical significance ( p = 0.068) ( Figure 2 ). 2.4.

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However, a parallel univariate GLM analysis including the anatomical site of thrombus development demonstrated a highly significant three-way interaction between PAI - 1 4G homozygosity (4G/4G), ACE D homozygosity (D/D), and thrombosis site (cerebral vs. other), which notably affects miRNA expression ( p = 0.006).

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