The Rab7-Epg5 and Rab39-ema modules cooperatively position autophagosomes for efficient lysosomal fusions.

In contrast, khc and klc RNAi caused the perinuclear accumulation of autolysosomes, which appeared larger than those in the controls, suggesting a trend, although this difference did not reach statistical significance ( Figure 9F, G, J and L ).

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