Comparative Prognostic Roles of β-Catenin Expression and Tumor-Stroma Ratio in Pancreatic Cancer: Neoadjuvant Chemotherapy vs. Upfront Surgery.

Curr Oncol · 2025 · PMC12563957 · PMID 41149498

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hedged sentences

0.0580

closest p · 1.2× alpha

0.0640

boldest claim

The sentences

a marginal trendp = 0.058so close (0.05 < p ≤ 0.1)

Resection margin status showed a marginal trend with TSR in the overall cohort ( p = 0.058): margin-negative resections were 35/37 (94.6%) in the TSR < 13% group versus 37/47 (78.7%) in the TSR ≥13% group.

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approached significancep = 0.060so close (0.05 < p ≤ 0.1)

The distribution of pT category approached significance ( p = 0.060); the NAC cohort included more pT1 and fewer pT2, with a modest excess of pT3 (NAC: pT1 13/35, 37.1%; pT2 13/35, 37.1%; pT3 9/35, 25.7% vs.

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marginal significancep = 0.064so close (0.05 < p ≤ 0.1)

In multivariate models, β-CTN/m-CK index < 0.5 (HR 2.230, 95% CI 1.106–4.500; p = 0.025) was the independent predictor of shorter RFS, and TSR ≥ 13% showed marginal significance for CSS (HR 2.536, 95% CI 0.947–6.790; p = 0.064).

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