Pan-Cancer Detection Through DNA Methylation Profiling Using Enzymatic Conversion Library Preparation with Targeted Sequencing.

When cancer cases were stratified by disease type, metastatic (median 16.5 ng/mL, IQR: 9.8–35.5 ng/mL, range: 5.8–76.7 ng/mL) and haematolymphoid malignancies (median 13.8 ng/mL, IQR: 9.3–22.0 ng/mL, range 4.6–59.3 ng/mL) showed higher median cfDNA concentrations and greater variability compared to localized cases (median 9.6 ng/mL, IQR: 6.3–12.8 ng/mL, range 2.6–27.5 ng/mL), although these differences did not reach statistical significance ( p = 0.06) (see Figure 1 B).

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