The Immunomodulatory Role of Gemcitabine in Triple Negative Breast Cancer.

While individual experiments did not reach statistical significance, after combining data, there was a small but significant increase in pan-MDSCs (GR1 + ) (1.1 FC, p = 0.0006) and granulocytic MDSCs (Ly6G + ) (1.1 FC, p = 0.0089) in the tumour, as well as a decrease in granulocytic MDSCs (0.7 FC, p = 0.0061) in the spleen ( Figure S4 ).

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While there were no significant changes, there was a small trend in decreasing tumour T-helper cells after GEM treatment.

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While changes in immune populations were observed in each individual experiment, variation within groups (which is expected in such studies) meant some of these findings failed to reach significance.

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