did not reach statistical significancep = 0.0839
This anxiety-like response was no longer observed in groups that received PO treatment ( p > 0.05), nor in VEH-treated animals; although they showed a tendency to anxiety, the reduction in center time from 85.73 ± 34.44 s to 49.04 ± 8.41 s did not reach statistical significance ( p = 0.0839, Cohen’s d = 1.46) ( Figure 2 b).