Raloxifene Is Associated with Total Knee Arthroplasty in Postmenopausal Women: A Comparative Cohort Study.

Discussion Our analysis of 6155 patients (mean follow-up: 5.47 years) found that raloxifene showed a trend toward lower TKR risk vs. bisphosphonates in crude analysis (HR 0.62, 95% CI 0.42–0.93, p = 0.022), but this association became non-significant in the traditional adjusted Cox model (aHR 0.71, 95% CI 0.47–1.07, p = 0.102).

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Crude TKR rates were 2.3% in the bisphosphonate group, 0.9% in the denosumab group, and 0.9% in the raloxifene group, with a borderline significant difference among the groups ( p = 0.052).

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