Investigation of the Effect of Enamel Matrix Protein, Platelet-Rich Fibrin, and Bone Graft on New Bone Formation in Guided Tissue Regeneration in Rat Calvarium.

Medicina (Kaunas) · 2025 · PMC12565760 · PMID 41155782

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did not reach statistical significanceno p-value reported

Consistent with these studies, in our study, the PRF group exhibited a higher rate of moderate new bone formation than the control group; however, this difference did not reach statistical significance. Nonetheless, using PRF alone supports new bone formation by enhancing vascularization and promoting osteogenic cell differentiation, suggesting that it is an effective material for GTR.

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