Bacterial Infections and Their Cell Wall Ligands Differentially Modulate Doxorubicin Sensitivity in Triple-Negative Breast Cancer Cells.

Microorganisms · 2025 · PMC12566298 · PMID 41156777

Europe PMC DOI

hedged sentences

0.0001

closest p · 0.0× alpha

0.1300

boldest claim

The sentences

highly significantp < 0.0001actually significant

Analysis of GMFI revealed parallel results, with highly significant MOI effects in MDA-MB-231 (F(2,6) = 427.7, p < 0.0001) and MDA-MB-468 (F(2,6) = 297.6, p < 0.0001), confirming robust dose-dependent increases in bacterial load, whereas MDA-MB-453 exhibited negligible changes.

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did not reach statistical significancep = 0.13not close (p > 0.1)

MDA-MB-231 showed a downward trend that did not reach statistical significance (slope –0.72 [95% CI: –1.78 to 0.35] log 10 CFU/day; p = 0.13), whereas MDA-MB-468 exhibited a significant decline (slope –0.72 [95% CI: –1.26 to –0.17] log 10 CFU/day; p = 0.02).

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