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Targeting Glycolysis with 2-Deoxy-D-Glucose and Lysosomal Integrity with L-Leucyl-L-Leucine Methyl Ester as Antimelanoma Strategy.

Pharmaceutics · 2025 · PMC12566822 · PMID 41155949

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In line with the latter, 2DG tended to reduce OXPHOS in our model, although this effect did not reach statistical significance, and the strongest OXPHOS inhibition was observed when both treatments were applied together ( Figure S1A and Figure 5 A).

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