Cytokine Profile and Oxidative Patterns in Murine Models of Disseminated Infection by Mucorales Species.

On the other hand, cytokines in the kidney show a negative trend, such as IL-6 (−0.48), indicating an association between the spleen and a pro-inflammatory response ( Figure 3 D).

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oryzae , a significant increase in the fungal load in the liver was observed on day 1, which decreased on day 3 ( Figure 1 A); in the spleen, only an increasing trend of CFU was observed on day 7 ( Figure 1 D), while no differences in kidney were observed ( Figure 1 G).

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oryzae showed a gradual increase in cytokines of the Th1 and Th17 profile from day 1 to day 7, showing a highly significant increase compared to controls and the others on the seventh day after infection ( Figure 2 A,D,G,J,M).

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